Its special pathological feature is A β deposition outside the nervous cells and amyloid plaque formation, tau protein over phosphorated and neural fibers twist. 其突出病理特征是脑神经细胞外β-淀粉样蛋白(Aβ)沉积与淀粉样斑块形成,tau蛋白过度磷酸化与神经原纤维缠结。
Morphological evidence of zinc ions involved in β-amyloid plaque formation in alzheimer's disease 锌离子参与阿尔茨海默病Aβ老年斑形成的形态学证据
On the other hand, the oligomers also act as nucleating seeds for the growth of amyloid plaque. 另外,寡聚体还扮演着形成淀粉样纤维的成核种子。
These findings suggest that cerebral inflammation has no direct effect on the early memory impairment in AD.3. After amyloid plaque deposition, cerebral inflammation in the brain of 12-month-old APP/ PS1 mice was significantly increased, and highly associated with the impaired spatial learning and memory. 在淀粉样斑块形成之后,12月龄APP/PS1小鼠脑内炎症反应显著增加且与其空间学习、记忆功能障碍密切相关,提示炎症反应在AD学习记忆障碍进展过程中具有重要作用。